rs6923761 gene variant in glucagon-like peptide 1 receptor: Allelic frequencies and influence on cardiovascular risk factors in a multicenter study of Castilla-Leon

D A de Luis; M Ballesteros; A Lopez Guzman; E Ruiz; C Muñoz; M A Penacho; P Iglesias; A Maldonado; V Puigdevall; M Delgado

doi:10.1016/j.clnu.2017.10.013

rs6923761 gene variant in glucagon-like peptide 1 receptor: Allelic frequencies and influence on cardiovascular risk factors in a multicenter study of Castilla-Leon

Clin Nutr. 2018 Dec;37(6 Pt A):2144-2148. doi: 10.1016/j.clnu.2017.10.013. Epub 2017 Nov 2.

Authors

Affiliations

¹ Center of Investigation of Endocrinology and Nutrition, Clinico Universitario, University of Valladolid, Valladolid Group of Nutrition and Obesity, SCLEDYN, Spain; Medicine School, Dept Endocrinology and Nutrition H(a), Clinico Universitario, University of Valladolid, Valladolid Group of Nutrition and Obesity, SCLEDYN, Spain; Groups of Nutrition and Obesity SCLEDYN, Spain. Electronic address: dadluis@yahoo.es.
² Groups of Nutrition and Obesity SCLEDYN, Spain.

PMID: 29128339
DOI: 10.1016/j.clnu.2017.10.013

Abstract

Background: Some GLP-1 receptor studies have identified polymorphisms in the GLP-1 receptor gene that might be related to different cardiovascular risk factors.

Objective: Our aim was to investigate the allelic distribution of rs6923761 GLP-1 receptor polymorphism in a geographic area of Spain (Community of Castilla y Leon) and to evaluate the influence of this polymorphism on obesity anthropometric parameters and cardiovascular risk factors in the fasted state in obese patients.

Design: A sample of 341 obese subjects (body mass index ≥ 30 kg/m²) was analyzed. Fasting blood glucose, C-reactive protein (CRP), plasma insulin, insulin resistance (HOMA-IR), and lipid profile were determined. Anthropometric parameters, dietary intake and blood pressure were recorded.

Results: One hundred and forty three patients (42.0%) had the genotype GG (wild-type group) and one hundred and ninety eight (58.0%) patients were A carriers: GA (164 patients, 48.1%) or AA (34 patients, 9.9%) (mutant-type group). Valladolid and Segovia health areas had the lowest percentage of wild type genotype and G allelic (than other Health Areas). Burgos Health Area had a higher percentage of wild-type genotype. In wild-type group (GG genotype), BMI (0.9 ± 1.3 kg/m²; p < 0.05), weight (3.3 ± 1.1 kg; p < 0.05), fat mass (2.5 ± 1.1 kg; p < 0.05), waist to hip ratio (0.02 ± 0.005 cm; p < 0.05), waist circumference (2.8 ± 1.1 cm; p < 0.05), triglycerides (14.4 ± 3.3 mg/dl; p < 0.05) insulin (3.1 ± 1.0 mg/dl; p < 0.05) and HOMA-IR (1.2 ± 0.9 mg/dl; p < 0.05) were higher than A allele carriers. In non A allele carriers, lower HDL cholesterol levels than A allele carriers (6.4 ± 2.3 mg/dl; p < 0.05) were found.

Conclusion: Data from our study revealed different allelic distribution in this geographic area, with better parameters (Body mass index, weight, fat mass, waist circumference, triglycerides, insulin, HOMA-IR and HDL cholesterol) in A allele carriers than in non A allele carriers.

Keywords: Cardiovascular risk factors; Glucagon-like peptide 1 receptor; Insulin resistance; Lipids; rs6923761.

Publication types

Multicenter Study
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Blood Glucose / analysis
Cardiovascular Diseases* / epidemiology
Cardiovascular Diseases* / genetics
Cross-Sectional Studies
Diet / statistics & numerical data
Female
Genetic Predisposition to Disease
Glucagon-Like Peptide-1 Receptor / genetics*
Humans
Insulin / blood
Male
Middle Aged
Obesity* / epidemiology
Obesity* / genetics
Risk Factors
Spain / epidemiology

Substances

Blood Glucose
GLP1R protein, human
Glucagon-Like Peptide-1 Receptor
Insulin