Lactadherin: An unappreciated haemostasis regulator and potential therapeutic agent

Vascul Pharmacol. 2018 Feb:101:21-28. doi: 10.1016/j.vph.2017.11.006. Epub 2017 Nov 21.

Abstract

Lactadherin is a small (53-66kDa) multifunctional glycoprotein belonging to the secreted extracellular matrix protein family. It has a multi-domain structure and is involved in many biological and physiological processes, including phagocytosis, angiogenesis, atherosclerosis, tissue remodeling, and haemostasis regulation. Lactadherin binds phosphatidylserine (PS)-enriched cell surfaces in a receptor-independent manner. Interaction between lactadherin and PS is crucial for regulation of blood coagulation processes. This review summarizes recent knowledge on the possible role of lactadherin in haemostasis control, emphasizing the great significance of the interaction between lactadherin and PS expressed on activated platelets and extracellular vesicles. The possible role of lactadherin as a therapeutic target and biomarker is also discussed.

Keywords: Coagulation; MFG-E8; Microvesicles; Phosphatidylserine; RGD.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anticoagulants / pharmacology
  • Antigens, Surface / chemistry
  • Antigens, Surface / metabolism*
  • Antigens, Surface / pharmacology
  • Binding Sites
  • Blood Platelets / drug effects
  • Blood Platelets / metabolism*
  • Extracellular Vesicles / drug effects
  • Extracellular Vesicles / metabolism*
  • Hemostasis* / drug effects
  • Humans
  • Milk Proteins / chemistry
  • Milk Proteins / metabolism*
  • Milk Proteins / pharmacology
  • Models, Molecular
  • Phosphatidylserines / metabolism*
  • Platelet Activation* / drug effects
  • Protein Conformation
  • Signal Transduction
  • Structure-Activity Relationship

Substances

  • Anticoagulants
  • Antigens, Surface
  • MFGE8 protein, human
  • Milk Proteins
  • Phosphatidylserines