Past and Future of Ga-citrate for Infection and Inflammation Imaging

Curr Pharm Des. 2018;24(7):787-794. doi: 10.2174/1381612824666171129200611.

Abstract

Both 67Ga and 68Ga-citrates are used to detect a wide spectrum of pathology consisting of various inflammatory, infectious and malignant conditions. Considering the now widespread availability and constantly increasing demand for PET/CT studies,68Ga-citrate is gaining ground in clinical settings and the added value of combined metabolic and anatomical imaging achieved by combining PET with Computed Tomography (CT) to PET/CT makes 68Ga-citrate particularly promising. Despite the tracer's non-specificity, it has demonstrated potential especially in the evaluation of various infectious and inflammatory skeletal- and lung conditions. In this review, we will focus on the indications and lessons learned from 67Ga, and present the current status for the use of 68Ga-citrate PET/CT in selected inflammation and infectious diseases based on the limited literature available.

Keywords: 68Ga-citrate; Computed Tomography (CT); Gallium; infection; inflammation; malignant conditions..

Publication types

  • Review

MeSH terms

  • Citrates / chemistry*
  • Communicable Diseases / diagnosis*
  • Gallium / chemistry*
  • Gallium Radioisotopes / chemistry*
  • Humans
  • Inflammation / diagnosis*
  • Positron Emission Tomography Computed Tomography*

Substances

  • Citrates
  • Gallium Radioisotopes
  • Gallium-67
  • Gallium
  • gallium citrate