Recent Progress in the Chemistry of Pyridazinones for Functional Group Transformations

J Org Chem. 2018 Jan 5;83(1):1-11. doi: 10.1021/acs.joc.7b02481. Epub 2017 Dec 11.

Abstract

While N-hetereocycles have received significant attention in organic synthesis and other research fields, the chemistry of pyridazine, a six-membered aromatic ring with two adjacent nitrogen atoms, and its derivatives has been relatively little understood. This Synopsis describes recent progress made in the synthesis of pyridazine derivatives-particularly, pyridazin-3(2H)-ones-and their utility as efficient and recyclable functional group carriers for various important organic reactions.