Postmortem examination results of a patient with Guillain-Barré syndrome and confirmed Zika virus infection revealed demyelination of the sciatic and cranial IV nerves, providing evidence of the acute demyelinating inflammatory polyneuropathy Guillain-Barré syndrome variant. Lack of evidence of Zika virus in nervous tissue suggests that pathophysiology was antibody mediated without neurotropism.
Keywords: Guillain-Barré syndrome; Puerto Rico; Zika virus; infectious disease pathophysiology; postmortem investigation; vector-borne infections; viruses.