Mechanoreciprocity in cell migration

Nat Cell Biol. 2018 Jan;20(1):8-20. doi: 10.1038/s41556-017-0012-0. Epub 2017 Dec 21.

Abstract

Cell migration is an adaptive process that depends on and responds to physical and molecular triggers. Moving cells sense and respond to tissue mechanics and induce transient or permanent tissue modifications, including extracellular matrix stiffening, compression and deformation, protein unfolding, proteolytic remodelling and jamming transitions. Here we discuss how the bi-directional relationship of cell-tissue interactions (mechanoreciprocity) allows cells to change position and contributes to single-cell and collective movement, structural and molecular tissue organization, and cell fate decisions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biomechanical Phenomena
  • Bone and Bones / cytology
  • Bone and Bones / metabolism
  • Brain / cytology
  • Brain / metabolism
  • Cell Communication / physiology*
  • Cell Differentiation
  • Cell Movement / physiology*
  • Eukaryotic Cells / cytology
  • Eukaryotic Cells / metabolism*
  • Extracellular Matrix / chemistry
  • Extracellular Matrix / metabolism
  • Humans
  • Mechanotransduction, Cellular / physiology*
  • Muscle, Skeletal / cytology
  • Muscle, Skeletal / metabolism
  • Organ Specificity
  • Proteolysis
  • Tendons / cytology
  • Tendons / metabolism