Nonalcoholic steatohepatitis and hepatic adenomatosis: casual or causal relationship?

Rev Esp Enferm Dig. 2018 Mar;110(3):204-206. doi: 10.17235/reed.2017.4981/2017.

Abstract

Hepatic adenomatosis is a benign disease defined as the presence of multiple adenomas in a normal liver. It is an uncommon condition and there are less than a hundred reported cases in the literature. The etiology is unknown, although it has been associated with the use of oral contraceptives, anabolic steroids, certain storage diseases and some genetic mutations linked to maturity onset diabetes of the young. The coexistence of hepatic adenomatosis and nonalcoholic steatohepatitis has been recently described in two patients suffering from metabolic syndrome. This association is particularly interesting due to the growing prevalence of nonalcoholic fatty liver disease in developed countries and the possibility of a common causal pathway. We report the case of a young woman with fructosemia and hepatic steatosis; multiple hepatic adenomas associated to steatohepatitis lesions were also found during clinical follow-up. The possible implications are discussed.

Publication types

  • Case Reports

MeSH terms

  • Adenoma / complications*
  • Adenoma / diagnostic imaging
  • Adenoma / pathology
  • Adult
  • Female
  • Fructose Intolerance / etiology
  • Hepatocyte Nuclear Factor 1
  • Humans
  • Liver Neoplasms / complications*
  • Liver Neoplasms / diagnostic imaging
  • Liver Neoplasms / pathology
  • Magnetic Resonance Imaging
  • Non-alcoholic Fatty Liver Disease / complications*
  • Non-alcoholic Fatty Liver Disease / diagnostic imaging
  • Non-alcoholic Fatty Liver Disease / pathology

Substances

  • Hepatocyte Nuclear Factor 1