Mild, calcium catalysed Beckmann rearrangements

Chem Commun (Camb). 2018 Jan 16;54(6):654-657. doi: 10.1039/c7cc09491d.

Abstract

A mild calcium catalysed Beckmann rearrangement has been realised, which forgoes the more traditional harsh reactions conditions associated with the transformation. The catalyst system is shown to be tolerant towards a wide variety of functional groups relevant to natural product synthesis and medicinal chemistry and the synthetic utility of the reaction has also been investigated. A preliminary mechanistic investigation was performed to understand the nature of the incoming nucleophile and a possible reaction pathway is described.