Interneuron synaptopathy in developing rat cortex induced by the pro-inflammatory cytokine LIF

Exp Neurol. 2018 Apr:302:169-180. doi: 10.1016/j.expneurol.2017.12.011. Epub 2018 Jan 2.
No abstract available

Keywords: Basket cell; Leukemia inhibitory factor; Neocortex; Plasticity; Synaptopathy; TrkB.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Newborn
  • Axons / drug effects
  • Brain-Derived Neurotrophic Factor / pharmacology
  • Calcium / metabolism
  • Dendrites / drug effects
  • In Vitro Techniques
  • Interneurons / cytology*
  • Interneurons / drug effects*
  • Interneurons / metabolism
  • Leukemia Inhibitory Factor / pharmacology*
  • Mitogen-Activated Protein Kinase Kinases / metabolism
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / metabolism
  • Neuropeptide Y / genetics
  • Neuropeptide Y / metabolism
  • Organ Culture Techniques
  • Rats
  • Rats, Long-Evans
  • Shaw Potassium Channels / genetics
  • Shaw Potassium Channels / metabolism
  • Synapses / drug effects*
  • Synaptotagmin II / genetics
  • Synaptotagmin II / metabolism
  • Time Factors
  • Visual Cortex / cytology*

Substances

  • Brain-Derived Neurotrophic Factor
  • Kcnc2 protein, rat
  • Leukemia Inhibitory Factor
  • Nerve Tissue Proteins
  • Neuropeptide Y
  • Shaw Potassium Channels
  • Synaptotagmin II
  • Syt2 protein, rat
  • Mitogen-Activated Protein Kinase Kinases
  • Calcium