Systematic review of plasma-membrane ecto-ATP synthase: A new player in health and disease

Abstract

This review summarizes recent studies on plasma-membrane ecto-ATP synthase from structural and functional standpoints to possible pathophysiological roles. This review discusses significant new contributions and perspectives in the area of ecto-ATP synthase since the topic was last reviewed in 2015. Following an extensive summary of the cell types in which the ecto-ATP synthase is present, its structural and functional mechanism are discussed and physiological and pathological roles of the ecto-ATP synthase are reviewed and evaluated. Attempts to define the possible role of ecto-ATP synthase as possible target for anti-cancer and anti-obesity interventions are discussed.

Keywords: Angiogenesis; Ecto-ATP-synthase; Extracellular ATP/ADP; IF(1); Lipid metabolism; pH regulation.