Clinical features of three patients with paradoxical immune reconstitution inflammatory syndrome associated with Talaromyces marneffei infection

Nguyen Tat Thanh; Le Duc Vinh; Nguyen Thanh Liem; Cecilia Shikuma; Jeremy N Day; Guy Thwaites; Thuy Le

doi:10.1016/j.mmcr.2016.12.005

Clinical features of three patients with paradoxical immune reconstitution inflammatory syndrome associated with Talaromyces marneffei infection

Med Mycol Case Rep. 2016 Dec 9:19:33-37. doi: 10.1016/j.mmcr.2016.12.005. eCollection 2018 Mar.

Authors

Nguyen Tat Thanh¹, Le Duc Vinh², Nguyen Thanh Liem², Cecilia Shikuma³, Jeremy N Day^{1

4}, Guy Thwaites^{1

4}, Thuy Le^{1

4

3}

Affiliations

¹ Oxford University Clinical Research Unit, 764 Vo Van Kiet, Quan 5, Ho Chi Minh City, Vietnam.
² Vietnam Hospital for Tropical Diseases, 764 Vo Van Kiet, Quan 5, Ho Chi Minh City, Vietnam.
³ Hawaii Center for AIDS, University of Hawaii at Manoa, 651 Ilalo St., BSB, Suite 231, Honolulu, HI 96813, USA.
⁴ Centre for Tropical Medicine and Global Health, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7FZ, UK.

Abstract

Talaromyces marneffei infection is a major cause of death in HIV-infected individuals in South and Southeast Asia. Talaromycosis immune reconstitution inflammatory syndrome has not been well described. Here we report the clinical features, management, and outcomes of three HIV-infected patients with talaromycosis-associated paradoxical immune reconstitution inflammatory syndrome in Ho Chi Minh City, Vietnam.

Keywords: HIV; Immune reconstitution inflammatory syndrome; Penicilliosis; Penicillium marneffei; Talaromyces marneffei; Talaromycosis.

Abstract

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