Metabolism in Pluripotent Stem Cells and Early Mammalian Development

Jin Zhang; Jing Zhao; Perrine Dahan; Vivian Lu; Cheng Zhang; Hu Li; Michael A Teitell

doi:10.1016/j.cmet.2018.01.008

Metabolism in Pluripotent Stem Cells and Early Mammalian Development

Cell Metab. 2018 Feb 6;27(2):332-338. doi: 10.1016/j.cmet.2018.01.008.

Authors

Jin Zhang¹, Jing Zhao², Perrine Dahan³, Vivian Lu⁴, Cheng Zhang⁵, Hu Li⁵, Michael A Teitell⁶

Affiliations

¹ The First Affiliated Hospital and Center for Stem Cell and Regenerative Medicine, Department of Basic Medical Sciences, School of Medicine, Institute of Hematology, Zhejiang University, Hangzhou, Zhejiang 310058, China. Electronic address: zhgene@zju.edu.cn.
² The First Affiliated Hospital and Center for Stem Cell and Regenerative Medicine, Department of Basic Medical Sciences, School of Medicine, Institute of Hematology, Zhejiang University, Hangzhou, Zhejiang 310058, China.
³ Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
⁴ Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
⁵ Center for Individualized Medicine, Department of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA.
⁶ Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: mteitell@mednet.ucla.edu.

PMID: 29414683
DOI: 10.1016/j.cmet.2018.01.008

Abstract

Emerging and seminal studies have shown that cell metabolism influences gene expression by modifying the epigenome, which can regulate stem cell pluripotency, differentiation, and somatic cell reprogramming. Core pluripotency factors and developmental regulators reciprocally control the expression of key metabolism genes and their encoded pathways. Recent technological advances enabling sensitive detection methods during early mammalian development revealed the state-specific and context-dependent coordination of signal transduction, histone modifications, and gene expression in developing, resting, and malnourished embryos. Here, we discuss metabolism as a potential driver of earliest cell fate through its influence on the epigenome and gene expression in embryos and their in vitro surrogate pluripotent stem cells.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Animals
Disease
Embryo, Mammalian / metabolism
Epigenesis, Genetic
Humans
Mammals / embryology*
Mammals / metabolism*
Metabolic Networks and Pathways
Pluripotent Stem Cells / metabolism*

Grants and funding

R01 CA185189/CA/NCI NIH HHS/United States