Fallopian Tube Mucosal Involvement in Cervical Gastric-type Adenocarcinomas: Report of a Series With Discussion of the Distinction From Synchronous In Situ Tubal Lesions

Am J Surg Pathol. 2018 Jun;42(6):813-820. doi: 10.1097/PAS.0000000000001039.

Abstract

Cervical gastric-type adenocarcinomas are aggressive non-human papillomavirus-related carcinomas with a propensity for extracervical spread, including unusual sites such as the omentum, peritoneum, and ovary. We report 7 cases of cervical gastric-type adenocarcinoma with fallopian tube involvement predominantly in the form of mucosal colonization without underlying invasion. As far as we are aware, this has not been previously described and this report adds to the literature regarding metastatic neoplasms, which may exhibit tubal mucosal involvement and mimic an in situ lesion at this site. In all cases, there was associated ovarian involvement and in 6 of 7 cases, there was endometrial colonization. We speculate that the fallopian tube (and ovarian) involvement is secondary to transuterine spread. Given the occasional occurrence of multifocal gastric-type glandular lesions (benign or malignant) involving different sites in the female genital tract, we discuss the distinction between synchronous independent and metastatic lesions.

Publication types

  • Multicenter Study

MeSH terms

  • Adenocarcinoma / chemistry
  • Adenocarcinoma / secondary*
  • Adenocarcinoma / surgery
  • Adult
  • Aged
  • Biomarkers, Tumor / analysis
  • Biopsy
  • Fallopian Tube Neoplasms / chemistry
  • Fallopian Tube Neoplasms / secondary*
  • Fallopian Tube Neoplasms / surgery
  • Fallopian Tubes / chemistry
  • Fallopian Tubes / pathology*
  • Fallopian Tubes / surgery
  • Female
  • Humans
  • Immunohistochemistry
  • Middle Aged
  • Mucous Membrane / chemistry
  • Mucous Membrane / pathology*
  • Mucous Membrane / surgery
  • Neoplasm Invasiveness
  • Northern Ireland
  • Ovarian Neoplasms / secondary
  • United States
  • Uterine Cervical Neoplasms / chemistry
  • Uterine Cervical Neoplasms / pathology*
  • Uterine Cervical Neoplasms / surgery

Substances

  • Biomarkers, Tumor