Plasmacytoid pre-dendritic cells (pDC): from molecular pathways to function and disease association

Solana Alculumbre; Salvatore Raieli; Caroline Hoffmann; Rabie Chelbi; François-Xavier Danlos; Vassili Soumelis

doi:10.1016/j.semcdb.2018.02.014

Plasmacytoid pre-dendritic cells (pDC): from molecular pathways to function and disease association

Semin Cell Dev Biol. 2019 Feb:86:24-35. doi: 10.1016/j.semcdb.2018.02.014. Epub 2018 Feb 19.

Authors

Solana Alculumbre¹, Salvatore Raieli¹, Caroline Hoffmann¹, Rabie Chelbi¹, François-Xavier Danlos¹, Vassili Soumelis²

Affiliations

¹ Institut Curie, PSL Research University, Institut National de la Santé et de la Recherche Médicale (INSERM), U932, F-75005 Paris, France.
² Institut Curie, PSL Research University, Institut National de la Santé et de la Recherche Médicale (INSERM), U932, F-75005 Paris, France. Electronic address: Vassili.soumelis@curie.fr.

PMID: 29444460
DOI: 10.1016/j.semcdb.2018.02.014

Abstract

Plasmacytoid pre-dendritic cells (pDC) are a specialized DC population with a great potential to produce large amounts of type I interferon (IFN). pDC are involved in the initiation of antiviral immune responses through their interaction with innate and adaptive immune cell populations. In a context-dependent manner, pDC activation can induce their differentiation into mature DC able to induce both T cell activation or tolerance. In this review, we described pDC functions during immune responses and their implication in the clearance or pathogenicity of human diseases during infection, autoimmunity, allergy and cancer. We discuss recent advances in the field of pDC biology and their implication for future studies.

Keywords: Adaptive immunity; Human diseases; Innate sensing; Plasmacytoid dendritic cells; Type I Interferon.

Publication types

Review

MeSH terms

Autoimmune Diseases / immunology*
Autoimmune Diseases / therapy
Dendritic Cells / immunology*
Humans
Hypersensitivity / immunology*
Hypersensitivity / therapy
Immunotherapy