[Early cell repair of the lung and the intestine in mice, after irradiation by fast neutrons and gamma rays]

C R Seances Soc Biol Fil. 1986;180(3):372-8.
[Article in French]

Abstract

Lung tolerance is assessed from LD50 at 180 days after thoracic irradiation, in mice, with d(50) + Be neutrons and 60Co gamma rays. Early intestinal tolerance is assessed from LD50 at 7 days after abdominal irradiation. Additional dose (Dr) to reach LD50 when a single dose Ds is split into 2 equal fractions Di separated by different time intervals "i", is determined (Dr = 2Di - Ds), Dr is larger after gamma than after neutron irradiation, for lung and intestine. After thoracic irradiation with gamma rays, Dr reaches 3.36, 4.38, 5.12 and 5.37 Gy for "i" = 2, 6, 12 and 24 hours respectively; after neutron irradiation, Dr reaches 0.66, 0.9, 1.29, 1.95 and 1.50 Gy for "i" = 1, 2, 4, 12 and 24 hours. Dr is smaller for intestine; after abdominal irradiation with gamma rays, it reaches 1.99, 2.59, 2.74, 3.11, 3.34, 4.44 and 4.56 Gy for "i" = 1, 2, 3.5, 8, 12, 18 and 24 hours; after neutron irradiation, it reaches 0.13, 0.45, 0.42 and 1.33 Gy for "i" = 1.5, 3.5, 5.5 and 24 hours. After gamma irradiation, early repair is complete after 3.5 hours for intestine and needs 12 hours for lung.

Publication types

  • English Abstract

MeSH terms

  • Abdomen / radiation effects
  • Animals
  • Cell Cycle
  • Fast Neutrons / adverse effects
  • Female
  • Gamma Rays
  • Intestines / cytology
  • Intestines / radiation effects*
  • Lethal Dose 50
  • Lung / cytology
  • Lung / radiation effects*
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Thorax / radiation effects
  • Time Factors