Zika virus: lessons learned in Brazil

Jose Luiz Proenca-Modena; Guilherme Paier Milanez; Maria Laura Costa; Carla C Judice; Fabio Trindade Maranhão Costa

doi:10.1016/j.micinf.2018.02.008

Zika virus: lessons learned in Brazil

Microbes Infect. 2018 Dec;20(11-12):661-669. doi: 10.1016/j.micinf.2018.02.008. Epub 2018 Mar 6.

Authors

Jose Luiz Proenca-Modena¹, Guilherme Paier Milanez², Maria Laura Costa³, Carla C Judice⁴, Fabio Trindade Maranhão Costa⁵

Affiliations

¹ Laboratory of Emerging Viruses, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas (Unicamp), Campinas, São Paulo, Brazil. Electronic address: jlmodena@unicamp.br.
² Laboratory of Emerging Viruses, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas (Unicamp), Campinas, São Paulo, Brazil.
³ Obstetrics and Gynecology Department, School of Medical Sciences, University of Campinas (Unicamp), Campinas, São Paulo, Brazil.
⁴ Laboratory of Tropical Diseases, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas (Unicamp), Campinas, São Paulo, Brazil.
⁵ Laboratory of Tropical Diseases, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas (Unicamp), Campinas, São Paulo, Brazil. Electronic address: costaftm@unicamp.br.

PMID: 29501560
DOI: 10.1016/j.micinf.2018.02.008

Abstract

Zika virus (ZIKV) greatly impacted the international scientific and public health communities in the last two years due to its association with microcephaly and other neonatal alterations. This review will discuss lessons learned from viral pathogenesis, epidemiology and clinical findings observed during the ZIKV outbreak occurred between 2014 and 2016 in Brazil.

Keywords: Arboviruses; Brazil; Epidemics setting; Pathogenesis; Transmission; Zika virus.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Brazil / epidemiology
Disease Outbreaks*
Female
Humans
Microcephaly / epidemiology
Microcephaly / etiology
Microcephaly / virology
Placenta / virology
Pregnancy
Viral Tropism
Zika Virus / pathogenicity*
Zika Virus / physiology
Zika Virus Infection / complications
Zika Virus Infection / epidemiology*
Zika Virus Infection / transmission
Zika Virus Infection / virology*