Abstract
Migraine is an extremely common but poorly understood nervous system disorder. We conceptualize migraine as a disorder of sensory network gain and plasticity, and we propose that this framing makes it amenable to the tools of current systems neuroscience.
Keywords:
allodynia; cortical spreading depression; gain; migraine; pain; photophobia; plasticity; systems neuroscience.
Copyright © 2018 Elsevier Inc. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Brain / physiopathology*
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Cortical Spreading Depression / physiology*
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Humans
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Migraine Disorders / physiopathology*
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Migraine Disorders / therapy
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Nerve Net / physiopathology
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Neuronal Plasticity / physiology*
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Neurosciences / methods
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Neurosciences / trends*
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Psychomotor Performance / physiology
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Systems Analysis*