Any sleep is a dream far away: a nominal group study assessing how gout affects sleep

Rheumatology (Oxford). 2018 Nov 1;57(11):1925-1932. doi: 10.1093/rheumatology/kex535.

Abstract

Objective: There are no qualitative studies of sleep in gout; the aim of this study was to examine the impact of gout on sleep.

Methods: Nine nominal groups were conducted, oversampling for African-Americans and women with gout. Patients discussed and rank-ordered their concerns.

Results: Nine nominal groups with 46 gout patients were conducted with mean age, 61 years (s.d. 10.6) and gout duration, 14.9 years (s.d. 12); 63% were men, 46% African-American, 52% married, 46% retired and 63% were allopurinol users. The most frequently cited highly ranked concerns could be divided into three categories. The first category, character of sleep interruption, included the concerns: severe and complete sleep interruption by gout flare pain (nine groups); and inability to get rapid eye movement sleep (one group). The second category, causes of sleep interruption, included: inability to get into a comfortable position during sleep (six groups); anxiety and depression associated with severe gout pain (seven groups); sleep interruption by moderate chronic joint pain (three groups); frequent trips to the bathroom interfering with sleep (two groups); gout medication side effects (four groups); frequent trips to the emergency room (one group); joint swelling with physical/functional deficit interfering with sleep (two groups); and flare pain interfering with sleep apnoea management (two groups). The final category, consequences of sleep interruption, included: effect on daily functioning (two groups); worsens other health conditions, which then affect sleep (four groups); and cumulative effect on sleep (one group).

Conclusion: Gout has significant impact on sleep quantity, quality and architecture. Sleep disruption due to gout has several pathways and significant consequences.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Aged
  • Allopurinol / therapeutic use
  • Anxiety / complications
  • Anxiety / physiopathology
  • Depression / complications
  • Depression / physiopathology
  • Febuxostat / therapeutic use
  • Female
  • Gout / complications*
  • Gout / drug therapy
  • Gout / physiopathology
  • Gout Suppressants / therapeutic use
  • Humans
  • Male
  • Middle Aged
  • Sleep / physiology*
  • Sleep Wake Disorders / etiology*
  • Sleep Wake Disorders / physiopathology

Substances

  • Gout Suppressants
  • Febuxostat
  • Allopurinol