Do SSRIs differ in their antidepressant efficacy

S Kasper; A Heiden

doi:10.1002/hup.470100905

Do SSRIs differ in their antidepressant efficacy

Hum Psychopharmacol. 1995 Oct;10 Suppl 3(S3):S163-S172. doi: 10.1002/hup.470100905.

Authors

S Kasper¹, A Heiden¹

Affiliation

¹ Department of General Psychiatry, University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria.

PMID: 29569410
DOI: 10.1002/hup.470100905

Abstract

Selective serotonin reuptake inhibitors (SSRIs) have been extensively studied worldwide and show at least equivalent efficacy to the tricyclic antidepressants (TCAs). Some of the SSRIs have demonstrated superior efficacy to TCAs in a number of subgroups including patients with severe depression, suicidal thoughts or depression associated with anxiety. There is currently a lack of direct comparative data between the different SSRIs, although the few studies which are available indicate overall equal efficacy. However, the pharmacodynamic and pharmacokinetic characteristics may result in different side-effects which might, in turn, lead to a characteristic pattern of use.

Keywords: depression; efficacy; selective serotonin reuptake inhibitors.