PLZF-expressing CD4 T cells show the characteristics of terminally differentiated effector memory CD4 T cells in humans

Eur J Immunol. 2018 Jul;48(7):1255-1257. doi: 10.1002/eji.201747426. Epub 2018 Apr 30.

Abstract

We show the presence of lymphoid tissue-resident PLZF+ CD45RA+ RO+ CD4 T cells in humans. They express HLA-DR, granzyme B, and perforin and are low on CCR7 like terminally differentiated effector memory (Temra) cells and are likely generated from effector T cells (Te) or from central (Tcm) or effector (Tem) memory T (Tcm) cells during immune responses. Tn, Naïve T cells.

Keywords: CD4 T cells; Human lymphoid tissue; PLZF; Temra cells.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural

MeSH terms

  • CD4-Positive T-Lymphocytes / physiology*
  • CD8-Positive T-Lymphocytes / immunology
  • Cell Differentiation
  • Cells, Cultured
  • Genotype*
  • Granzymes / metabolism
  • HLA-DR Antigens / metabolism
  • Humans
  • Immunity, Cellular
  • Immunologic Memory
  • Lymphoid Tissue / immunology*
  • Perforin / metabolism
  • Promyelocytic Leukemia Zinc Finger Protein / metabolism*
  • T-Lymphocyte Subsets / physiology*

Substances

  • HLA-DR Antigens
  • Promyelocytic Leukemia Zinc Finger Protein
  • Perforin
  • Granzymes