Neurovascular Communication during CNS Development

Isidora Paredes; Patricia Himmels; Carmen Ruiz de Almodóvar

doi:10.1016/j.devcel.2018.01.023

Neurovascular Communication during CNS Development

Dev Cell. 2018 Apr 9;45(1):10-32. doi: 10.1016/j.devcel.2018.01.023.

Authors

Isidora Paredes¹, Patricia Himmels¹, Carmen Ruiz de Almodóvar²

Affiliations

¹ Biochemistry Center, Heidelberg University, 69120 Heidelberg, Germany; Interdisciplinary Center for Neurosciences, Heidelberg University, 69120 Heidelberg, Germany.
² Biochemistry Center, Heidelberg University, 69120 Heidelberg, Germany; Interdisciplinary Center for Neurosciences, Heidelberg University, 69120 Heidelberg, Germany. Electronic address: carmen.ruizdealmodovar@bzh.uni-heidelberg.de.

PMID: 29634931
DOI: 10.1016/j.devcel.2018.01.023

Abstract

A precise communication between the nervous and the vascular systems is crucial for proper formation and function of the central nervous system (CNS). Interestingly, this communication does not only occur by neural cells regulating the growth and properties of the vasculature, but new studies show that blood vessels actively control different neurodevelopmental processes. Here, we review the current knowledge on how neurons in particular influence growing blood vessels during CNS development and on how vessels participate in shaping the neural compartment. We also review the identified molecular mechanisms of this bidirectional communication.

Keywords: CNS development; CNS vascularization; angiocrine cue; brain; neurodevelopment; neurovascular communication; neurovascular link; retina; spinal cord; vascular control of neuronal development and function.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Central Nervous System / blood supply
Central Nervous System / growth & development*
Humans
Neovascularization, Physiologic / physiology*