The effect of storage solutions, gene therapy, and antiproliferative agents on endothelial function and saphenous vein graft patency

J Card Surg. 2018 May;33(5):235-242. doi: 10.1111/jocs.13608. Epub 2018 Apr 23.

Abstract

Vein graft failure remains a major concern after coronary artery bypass graft operations, and is initiated by loss of endothelial cell integrity. Preservation of saphenous vein grafts in the optimal solution after meticulous harvesting can limit the endothelial damage. Despite both experimental and clinical results in favor of buffered solutions, normal saline is still the most widely used solution. This review examines the literature to identify the most optimal storage solutions currently available for vein graft preservation.

Keywords: cardiovascular research; coronary artery bypass graft surgery; storage solution; vein graft; vein graft failure.

Publication types

  • Review

MeSH terms

  • Buffers
  • Cell Proliferation
  • Coronary Artery Bypass*
  • Endothelial Cells / physiology*
  • Genetic Therapy*
  • Graft Rejection / etiology
  • Graft Rejection / prevention & control
  • Graft Survival*
  • Humans
  • Organ Preservation / methods*
  • Organ Preservation Solutions*
  • Saphenous Vein / transplantation*
  • Sodium Chloride
  • Solutions
  • Vascular Patency*

Substances

  • Buffers
  • Organ Preservation Solutions
  • Solutions
  • Sodium Chloride