Expression of Siglec-8 is regulated by interleukin-5, and serum levels of soluble Siglec-8 may predict responsiveness of severe eosinophilic asthma to mepolizumab

Allergol Int. 2018 Sep:67S:S41-S44. doi: 10.1016/j.alit.2018.03.006. Epub 2018 Apr 24.

Authors

Affiliations

¹ National Hospital Organization, Tokyo National Hospital, Tokyo, Japan; Department of Respiratory Medicine, University of Tokyo, Tokyo, Japan.
² National Hospital Organization, Tokyo National Hospital, Tokyo, Japan. Electronic address: fueta-tky@umin.ac.jp.
³ National Hospital Organization, Tokyo National Hospital, Tokyo, Japan.
⁴ Department of Respiratory Medicine, University of Tokyo, Tokyo, Japan.

PMID: 29703694
DOI: 10.1016/j.alit.2018.03.006

No abstract available

Publication types

Letter

MeSH terms

Aged
Antibodies, Monoclonal, Humanized / therapeutic use*
Antigens, CD / blood
Antigens, CD / genetics
Antigens, CD / metabolism*
Antigens, Differentiation, B-Lymphocyte / blood
Antigens, Differentiation, B-Lymphocyte / genetics
Antigens, Differentiation, B-Lymphocyte / metabolism*
Asthma / diagnosis*
Asthma / drug therapy*
Asthma / metabolism*
Biomarkers
Eosinophilia / pathology*
Female
Gene Expression
Humans
Interleukin-5 / blood
Interleukin-5 / metabolism*
Lectins / blood
Lectins / genetics
Lectins / metabolism*
Male
Middle Aged
Respiratory Function Tests

Substances

Antibodies, Monoclonal, Humanized
Antigens, CD
Antigens, Differentiation, B-Lymphocyte
Biomarkers
Interleukin-5
Lectins
SIGLEC8 protein, human
mepolizumab