First-in-class oral small molecule inhibitor of the tyrosine kinase ROR1 (KAN0439834) induced significant apoptosis of chronic lymphocytic leukemia cells

Leukemia. 2018 Oct;32(10):2291-2295. doi: 10.1038/s41375-018-0113-1. Epub 2018 Mar 27.

M Hojjat-Farsangi¹, A H Daneshmanesh¹, A S Khan¹, J Shetye¹, F Mozaffari¹, P Kharaziha¹, L-S Rathje^{1

2}, P Kokhaei^{1

3}, L Hansson^{1

4}, J Vågberg², S Byström², E Olsson², C Löfberg², C Norström², J Schultz², M Norin², T Olin², A Österborg^{1

4}, H Mellstedt⁵, A Moshfegh^{1

2}

¹ Department of Oncology-Pathology, Immune and Gene Therapy Lab, CancerCenterKarolinska (CCK), Karolinska University Hospital Solna and Karolinska Institute, Stockholm, Sweden.
² Kancera AB, Solna, Sweden.
³ Cancer Research Center and Department of Immunology, Semnan University of Medical Sciences, Semnan, Iran.
⁴ Department of Hematology, Karolinska University Hospital Solna, Stockholm, Sweden.
⁵ Department of Oncology-Pathology, Immune and Gene Therapy Lab, CancerCenterKarolinska (CCK), Karolinska University Hospital Solna and Karolinska Institute, Stockholm, Sweden. hakan.mellstedt@sll.se.

No abstract available

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