Human heart transplantation from donation after circulatory-determined death donors using normothermic regional perfusion and cold storage

Simon Messer; Aravinda Page; Simon Colah; Richard Axell; Barbora Parizkova; Steven Tsui; Stephen Large

doi:10.1016/j.healun.2018.03.017

Human heart transplantation from donation after circulatory-determined death donors using normothermic regional perfusion and cold storage

J Heart Lung Transplant. 2018 Jul;37(7):865-869. doi: 10.1016/j.healun.2018.03.017. Epub 2018 Mar 30.

Authors

Simon Messer¹, Aravinda Page¹, Simon Colah¹, Richard Axell¹, Barbora Parizkova¹, Steven Tsui¹, Stephen Large²

Affiliations

¹ Department of Transplantation, Papworth Hospital NHS Foundation Trust, Papworth Everard, Cambridgeshire, UK.
² Department of Transplantation, Papworth Hospital NHS Foundation Trust, Papworth Everard, Cambridgeshire, UK. Electronic address: s.large@nhs.net.

PMID: 29731238
DOI: 10.1016/j.healun.2018.03.017

Abstract

Heart transplantation from donation after circulatory-determined-death (DCD) donors is emerging as an additional avenue to increase heart transplant activity. Previous methods of DCD heart retrieval include direct procurement and cold storage, direct procurement, and machine perfusion and normothermic regional perfusion, followed by machine perfusion during transportation. Herein we report a further technique resulting in successful DCD heart transplantation utilizing normothermic regional perfusion and permitting functional assessment followed by cold storage.

Keywords: donation after circulatory death; heart; normothermic regional perfusion; organ donation; transplant.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Cold Temperature
Death*
Female
Heart Transplantation*
Humans
Male
Middle Aged
Organ Preservation / methods*
Perfusion
Tissue and Organ Procurement*