Sleep-related motor and behavioral disorders: Recent advances and new entities

Mov Disord. 2018 Jul;33(7):1042-1055. doi: 10.1002/mds.27375. Epub 2018 May 14.

Abstract

Patients with sleep-related motor and behavioral disorders present to a variety of subspecialty clinics (neurology, sleep medicine, respiratory medicine, psychiatry). Diagnosing these disorders can be difficult, and sometimes they have a significant impact on quality of life. Alongside a number of common and well-recognized conditions, several new disease entities have been described in recent years that present with abnormal nocturnal motor phenomena (such as ADCY5-associated disease and anti-IgLON5 disease). Our understanding of the neural basis and prognostic significance of other sleep-related disorders has also grown, particularly rapid eye movement sleep behavior disorder. This review (along with a collection of previously unpublished videos) is intended to aid in the recognition and treatment of these patients. The recent change in terminology from nocturnal frontal lobe epilepsy to sleep-related hypermotor epilepsy is also discussed. © 2018 International Parkinson and Movement Disorder Society.

Keywords: behavioral; motor; movement disorders; nocturnal; sleep.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Humans
  • Mental Disorders / diagnosis
  • Mental Disorders / etiology*
  • Mental Disorders / therapy
  • Movement Disorders / diagnosis
  • Movement Disorders / etiology*
  • Movement Disorders / therapy
  • Sleep Wake Disorders / complications*