Stability of Chromatin Remodeling Complex Subunits Is Determined by Their Phosphorylation Status

A M Azieva; A A Sheinov; F A Galkin; S G Georgieva; N V Soshnikova

doi:10.1134/S1607672918020035

Stability of Chromatin Remodeling Complex Subunits Is Determined by Their Phosphorylation Status

Dokl Biochem Biophys. 2018 Mar;479(1):66-68. doi: 10.1134/S1607672918020035. Epub 2018 May 19.

Authors

A M Azieva^{1

2}, A A Sheinov¹, F A Galkin¹, S G Georgieva³, N V Soshnikova⁴

Affiliations

¹ Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia.
² Kurchatov Institute National Research Center, Moscow, 123182, Russia.
³ Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
⁴ Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia. so2615nat@gmail.com.

PMID: 29779098
DOI: 10.1134/S1607672918020035

Abstract

It was found that, in the differentiated cells of mouse brain, the level of core (Brg1 and BAF155) and specific (BRD7, BAF180, and PHF10) subunits of the chromatin-remodeling complex PBAF is reduced compared to the undifferentiated proliferating cells. Phosphorylation of PBAF complex subunits is required for maintaining their stability in differentiated brain cells.

MeSH terms

Animals
Brain / cytology
Brain / metabolism*
Cell Differentiation
Cell Proliferation
Chromatin Assembly and Disassembly*
Chromosomal Proteins, Non-Histone / metabolism
Mice
Phosphorylation
Transcription Factors / metabolism

Substances

Chromosomal Proteins, Non-Histone
SWI-SNF-B chromatin-remodeling complex
Transcription Factors