NK-cell activation is associated with increased HIV transcriptional activity following allogeneic hematopoietic cell transplantation

Blood Adv. 2018 Jun 26;2(12):1412-1416. doi: 10.1182/bloodadvances.2018016329.

Abstract

  1. Graft-versus-host effects may lead to HIV-1 reactivation and cell death of infected pre-HCT CD4+ T cells.

  2. Natural killer cell activation correlates with in vitro HIV-1 transcriptional activity in the setting of HCT.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • CD4-Positive T-Lymphocytes / pathology
  • CD4-Positive T-Lymphocytes / virology
  • Cell Death
  • Graft vs Host Disease / virology
  • HIV Infections / therapy*
  • HIV-1 / genetics*
  • Hematopoietic Stem Cell Transplantation / methods*
  • Humans
  • Killer Cells, Natural / immunology*
  • Killer Cells, Natural / virology
  • Lymphocyte Activation
  • Transcription, Genetic
  • Transplantation, Homologous
  • Virus Activation