1-Benzyl-4-methylpiperidinyl moiety in donepezil: The priority ticket across the blood-brain-barrier in rats

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Aug 15:1092:350-358. doi: 10.1016/j.jchromb.2018.06.034. Epub 2018 Jun 18.
No abstract available

Keywords: Active transport; Blood-brain barrier; Brain targeting; Donepezil; UHPLC-MS; Validation.

MeSH terms

  • Animals
  • Biological Transport
  • Blood-Brain Barrier / metabolism*
  • Chromatography, High Pressure Liquid
  • Donepezil
  • Indans* / blood
  • Indans* / chemistry
  • Indans* / pharmacokinetics
  • Linear Models
  • Male
  • Piperidines* / blood
  • Piperidines* / chemistry
  • Piperidines* / pharmacokinetics
  • Rats
  • Rats, Wistar
  • Reproducibility of Results
  • Sensitivity and Specificity

Substances

  • Indans
  • Piperidines
  • Donepezil