Mitochondrial Dysfunction and Signaling in Chronic Liver Diseases

Gastroenterology. 2018 Sep;155(3):629-647. doi: 10.1053/j.gastro.2018.06.083. Epub 2018 Aug 2.

Abstract

Mitochondria regulate hepatic lipid metabolism and oxidative stress. Ultrastructural mitochondrial lesions, altered mitochondrial dynamics, decreased activity of respiratory chain complexes, and impaired ability to synthesize adenosine triphosphate are observed in liver tissues from patients with alcohol-associated and non-associated liver diseases. Increased lipogenesis with decreased fatty acid β-oxidation leads to the accumulation of triglycerides in hepatocytes, which, combined with increased levels of reactive oxygen species, contributes to insulin resistance in patients with steatohepatitis. Moreover, mitochondrial reactive oxygen species mediate metabolic pathway signaling; alterations in these pathways affect development and progression of chronic liver diseases. Mitochondrial stress and lesions promote cell death, liver fibrogenesis, inflammation, and the innate immune responses to viral infections. We review the involvement of mitochondrial processes in development of chronic liver diseases, such as nonalcoholic fatty, alcohol-associated, and drug-associated liver diseases, as well as hepatitis B and C, and discuss how they might be targeted therapeutically.

Keywords: HBV; HCV; NAFLD; NASH; ROS.

Publication types

  • Review

MeSH terms

  • End Stage Liver Disease / etiology*
  • End Stage Liver Disease / physiopathology
  • Humans
  • Lipid Metabolism / physiology
  • Liver / physiopathology
  • Mitochondria, Liver / physiology*
  • Mitochondrial Diseases / complications*
  • Mitochondrial Diseases / physiopathology
  • Oxidative Stress / physiology
  • Reactive Oxygen Species / metabolism
  • Signal Transduction / physiology*

Substances

  • Reactive Oxygen Species