Antiemetics, Selective 5-HT3 Antagonists

Excerpt

Selective serotonin receptor (5-HT3) antagonists block serotonin, specifically targeting gastrointestinal (GI) vagal nerve terminals and the chemoreceptor trigger zone within the central nervous system. This blockade leads to antiemetic effects, making them invaluable in managing nausea and vomiting induced by chemotherapy, radiation therapy, and postoperative procedures. Understanding the indications, dosing, administration, and potential adverse events associated with 5-HT3 receptor antagonists is crucial for healthcare professionals across disciplines. This activity provides comprehensive insights into the pharmacological mechanism, pharmacokinetics, contraindications, precautions, monitoring strategies, and toxicity profiles of these agents, emphasizing the collaborative efforts of interdisciplinary healthcare teams in effectively preventing and treating nausea and vomiting.