pSTAT3+ Reactive Astrocytes Promote Brain Metastasis

Minhong Shen; Yibin Kang

doi:10.1016/j.molmed.2018.07.002

pSTAT3⁺ Reactive Astrocytes Promote Brain Metastasis

Trends Mol Med. 2018 Sep;24(9):733-735. doi: 10.1016/j.molmed.2018.07.002. Epub 2018 Jul 17.

Authors

Minhong Shen¹, Yibin Kang²

Affiliations

¹ Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
² Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA. Electronic address: ykang@princeton.edu.

PMID: 30029985
DOI: 10.1016/j.molmed.2018.07.002

Abstract

The tumor microenvironment contains heterogeneous populations of stromal cells with important roles in cancer progression and metastasis. In a recent study published in Nature Medicine, pSTAT3⁺ reactive astrocytes were found to promote brain metastasis by altering the tumor microenvironment, and represent a promising target for the treatment of brain metastasis.

Publication types

Comment

MeSH terms

Astrocytes*
Brain
Brain Neoplasms*
Humans
STAT3 Transcription Factor
Stromal Cells
Tumor Microenvironment

Substances

STAT3 Transcription Factor
STAT3 protein, human