[Neurologic disorders and Hepatitis E: Review of literature]

Abstract

Introduction: Hepatitis E is an emerging, worldwide disease. It is often asymptomatic. Nevertheless, in few cases, clinical manifestation such as neurological disorder could be present. The aim of this article is to realize a literature review of the neurological symptoms associated with hepatitis E.

Methods: We searched the Pubmed database using the term "hepatitis E", "neurological disorder AND hepatitis E".

Results: One hundred and thirty cases have been described between 2000 and 2017. The majority of cases were associated with the genotype 3 and were reported in Europe or in Asia. It preferentially affected immunocompetent (93%) men with a median age of 52 years. The main neurologic disorders were Guillain-Barré syndrome (54 cases), Parsonage-Turner syndrome (35 cases), multiplex mononeuropathy (6 cases), meningitis and meningoencephalitis (9 cases). The diagnosis was done with HEV IgM serology in most cases (98%). Aminotranferases increase and cholestasis were found in 88% and 82% respectively. The outcome varied according to the neurological syndrome. Antiviral or immunomodulatory therapies did not seem to improve symptoms.

Conclusion: Hepatitis E seems to be associated with acute, wide neurological disorders. These data should be confirmed with a long term prospective study.

Keywords: Acute hepatitis; Hepatitis E; Hépatite E; Hépatite aiguë; Neurological disorder; Trouble neurologique.