Genetic Diversity of Noroviruses Circulating in a Pediatric Cohort in Bangladesh

J Infect Dis. 2018 Nov 5;218(12):1937-1942. doi: 10.1093/infdis/jiy454.

Abstract

Noroviruses are a leading cause of diarrhea in children aged <5 years worldwide. We genotyped 88 viruses collected by active surveillance in a birth cohort of children <2 years of age in Dhaka, Bangladesh, during 2010-2013. Twenty-five of 31 (81%) established GI and GII genotypes were detected, with GII.4 as the predominant genotype (20%). Our results show that children in Bangladesh are infected with a great diversity of norovirus strains. Reinfections are common, but not with closely related genotypes. Birth cohort studies are critical to understand cross-protective immunity and advance the development of pediatric norovirus vaccines.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bangladesh / epidemiology
  • Caliciviridae Infections / epidemiology*
  • Caliciviridae Infections / virology*
  • Capsid Proteins / genetics
  • Cohort Studies
  • Diarrhea / epidemiology
  • Diarrhea / virology*
  • Feces / virology
  • Female
  • Genetic Variation*
  • Genotype
  • Humans
  • Infant
  • Male
  • Norovirus / genetics*
  • Phylogeny

Substances

  • Capsid Proteins