Highly cytotoxic natural killer cells are associated with poor prognosis in patients with cutaneous T-cell lymphoma

Blood Adv. 2018 Aug 14;2(15):1818-1827. doi: 10.1182/bloodadvances.2018020388.

Abstract

  1. Paradoxically higher NK-cell activity in CTCL patients is associated with increased expression of phosphorylated STAT5.

  2. These highly effective NK cells are associated with poor prognosis in patients with leukemic CTCL.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Female
  • Humans
  • K562 Cells
  • Killer Cells, Natural / immunology*
  • Killer Cells, Natural / pathology
  • Lymphoma, T-Cell, Cutaneous / immunology*
  • Lymphoma, T-Cell, Cutaneous / mortality*
  • Lymphoma, T-Cell, Cutaneous / pathology
  • Male
  • Middle Aged