Pediatric cutaneous T-cell post-transplant lymphoproliferative disorder: Case report and review of the literature

Thomas S Rogers; Laura McGevna; Deborah L Cook

doi:10.1111/cup.13331

Pediatric cutaneous T-cell post-transplant lymphoproliferative disorder: Case report and review of the literature

J Cutan Pathol. 2018 Nov;45(11):858-863. doi: 10.1111/cup.13331. Epub 2018 Aug 22.

Authors

Thomas S Rogers^{1

2}, Laura McGevna^{2

3}, Deborah L Cook^{1

2}

Affiliations

¹ Department of Pathology and Laboratory Medicine, University of Vermont Medical Center, Burlington, Vermont.
² The Robert Larner MD College of Medicine, The University of Vermont, Burlington, Vermont.
³ Division of Dermatology, University of Vermont Medical Center, Burlington, Vermont.

PMID: 30054921
DOI: 10.1111/cup.13331

Abstract

Post-transplant lymphoproliferative disease (PTLD) is a rare lymphoid and/or plasmacytic proliferation that occurs in the context of immunosuppression because of solid organ transplantation (SOT) and allogeneic hematopoietic stem cell transplantation (HSCT). PTLD is the most common cancer in children who receive a SOT or HSCT, occurring in up to 13% of these patients. The majority of PTLDs are extracutaneous B-cell lymphomas, with only 12% to 14%, representing the T-cell phenotype. PTLDs can involve the skin and behave like an aggressive lymphoma, and are among the most serious and potentially fatal complications of transplantation. Here we present a case report and review of the literature of pediatric cutaneous PTLD.

Keywords: cutaneous lymphoma; pediatric; post-transplant lymphoproliferative disorder.

Publication types

Case Reports
Review

MeSH terms

Child
Fatal Outcome
Female
Humans
Immunocompromised Host*
Intestine, Small / transplantation*
Liver Transplantation / adverse effects*
Lymphoma, T-Cell, Cutaneous / immunology*
Lymphoma, T-Cell, Cutaneous / pathology*
Skin Neoplasms / immunology*
Skin Neoplasms / pathology*