Utility of diffusion-weighted magnetic resonance imaging in the diagnosis of cholesteatoma and the influence of the learning curve

Eur Arch Otorhinolaryngol. 2018 Sep;275(9):2227-2235. doi: 10.1007/s00405-018-5074-5. Epub 2018 Jul 28.

Abstract

Objective: The aim of this study is to assess the usefulness and reliability of this technique in our center, correlating the radiological and surgical findings and to study the influence of the learning curve by comparing the initial results with a radiological analysis performed 3 years after.

Study design: Retrospective cohort study.

Methods: 67 patients with clinical cholesteatoma suspicion were included in the study, 24 with previously not operated cholesteatoma and 43 with suspicion of recurrent or residual cholesteatoma. All of them underwent diffusion-weighted magnetic resonance imaging, comparing these results with the histological confirmation after surgery. At 3 years, a blind radiological review of these cases was performed and the results were compared with those obtained after the first assessment to objectify the influence of the learning curve.

Results: The sensitivity, specificity, positive predictive value, and negative predictive value of the total sample were 93.9, 77.8, 92 and 82.4. The overall results after the blind review of the cases were 95.9, 94.4, 97.9 and 89.5, respectively.

Conclusion: The diffusion-weighted magnetic resonance imaging is a very useful technique during the diagnostic process of doubtful cases of cholesteatoma, especially in cases of follow-up. As for the influence of the learning curve, we observed a clear improvement in the specificity of the test.

Keywords: Cholesteatoma; Diffusion-weighted magnetic resonance imaging; EPI DW-MRI; Middle ear cholesteatoma; Non-EPI DW-MRI; Second-look surgery.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Child
  • Cholesteatoma, Middle Ear / diagnostic imaging*
  • Cholesteatoma, Middle Ear / surgery
  • Diffusion Magnetic Resonance Imaging*
  • Female
  • Humans
  • Learning Curve*
  • Male
  • Middle Aged
  • Prospective Studies
  • Radiography
  • Reproducibility of Results
  • Retrospective Studies
  • Sensitivity and Specificity
  • Young Adult