Cyclical Dedifferentiation and Redifferentiation of Mammary Adipocytes

Callie A S Corsa; Ormond A MacDougald

doi:10.1016/j.cmet.2018.07.013

Cyclical Dedifferentiation and Redifferentiation of Mammary Adipocytes

Cell Metab. 2018 Aug 7;28(2):187-189. doi: 10.1016/j.cmet.2018.07.013.

Authors

Callie A S Corsa¹, Ormond A MacDougald²

Affiliations

¹ Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI 48105, USA.
² Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI 48105, USA. Electronic address: macdouga@umich.edu.

Abstract

Adipocytes are generally thought to be terminally differentiated cells; however, recent evidence suggests a subset may have greater plasticity in certain contexts. In this issue of Cell Metabolism, Wang et al. (2018) demonstrate a novel capacity for mammary adipocytes to dedifferentiate into preadipocyte-like precursors during lactation and redifferentiate upon weaning.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Adipocytes, White*
Cell Differentiation
Female
Humans
Lactation*
Weaning

Abstract

Publication types

MeSH terms

Grants and funding