Burkholderia multivorans septicemia in a pediatric liver transplant patient

Am J Transplant. 2019 Mar;19(3):933-938. doi: 10.1111/ajt.15065. Epub 2018 Sep 5.

Abstract

"Cepacia syndrome", caused by Burkholderia cepacia complex and often associated with cystic fibrosis, carries a high mortality rate. It is rare for Burkholderia multivorans, a species within the B. cepacia complex, to cause cepacia syndrome even among patients with cystic fibrosis. This is the first reported fatal case of cepacia syndrome caused by B. multivorans occurring in a pediatric liver transplant recipient who does not have cystic fibrosis. We describe the unique characteristics of this pathogen among the non-cystic fibrosis population and the importance of early recognition and treatment.

Keywords: clinical research/ practice; infection and infectious agents - bacterial; infectious disease; liver transplantation/hepatology; lung disease: infectious.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Burkholderia Infections / complications
  • Burkholderia Infections / microbiology*
  • Burkholderia cepacia complex / pathogenicity*
  • Fatal Outcome
  • Fever of Unknown Origin / pathology
  • Fever of Unknown Origin / surgery*
  • Humans
  • Infant
  • Liver Transplantation / adverse effects*
  • Male
  • Sepsis / etiology*
  • Sepsis / pathology