Deletion of the immunoglobulin heavy chain 3' regulatory region super-enhancer affects somatic hypermutation in B1 B cells

Cell Mol Immunol. 2019 Feb;16(2):195-197. doi: 10.1038/s41423-018-0091-2. Epub 2018 Aug 20.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3' Flanking Region / genetics*
  • Animals
  • B-Lymphocytes / immunology*
  • Cells, Cultured
  • Cytidine Deaminase / deficiency
  • Enhancer Elements, Genetic*
  • Immunoglobulin Heavy Chains / genetics*
  • Mice
  • Regulatory Sequences, Nucleic Acid / genetics*
  • Sequence Deletion
  • Somatic Hypermutation, Immunoglobulin*

Substances

  • Immunoglobulin Heavy Chains
  • AICDA (activation-induced cytidine deaminase)
  • Cytidine Deaminase