Statistical Shape Model to Generate a Planning Library for Cervical Adaptive Radiotherapy

IEEE Trans Med Imaging. 2019 Feb;38(2):406-416. doi: 10.1109/TMI.2018.2865547. Epub 2018 Aug 16.

Abstract

External beam radiotherapy is extensively used to treat cervical carcinomas. A single planning CT scan enables the calculation of the dose distribution. The treatment is delivered over five weeks. Large per-treatment anatomical variations may hamper the dose delivery, with the potential of an organ-at-risk (OAR) overdose and a tumor underdose. To anticipate these deformations, a recent approach proposed three planning CTs with variable bladder volumes, which had the limitation of not covering all per-treatment anatomical variations. An original patient-specific population-based library has been proposed. It consisted of generating two representative anatomies, in addition to the standard planning CT anatomy. First, the cervix and bladder meshes of a population of 20 patients (314 images) were registered to an anatomical template, using a deformable mesh registration. An iterative point-matching algorithm was developed based on local shape context (histogram of polar or cylindrical coordinates and geodesic distance to the base) and on a topology constraint filter. Second, a standard principal component analysis (PCA) model of the cervix and bladder was generated to extract the dominant deformation modes. Finally, specific deformations were obtained using posterior PCA models, with a constraint representing the top of the uterus deformation. For a new patient, the cervix-uterus and bladder were registered to the template, and the patient's modeled planning library was built according to the model deformations. This method was applied following a leave-one-patient-out cross-validation. The performances of the modeled library were compared to those of the three-CT-based library, showing an improvement in both target coverage and OAR sparing.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cervix Uteri / diagnostic imaging
  • Databases, Factual
  • Female
  • Humans
  • Image Processing, Computer-Assisted / methods*
  • Models, Statistical*
  • Pelvis / diagnostic imaging
  • Radiotherapy Planning, Computer-Assisted / methods*
  • Reproducibility of Results
  • Urinary Bladder / diagnostic imaging
  • Uterine Cervical Neoplasms / diagnostic imaging
  • Uterine Cervical Neoplasms / radiotherapy