Minimal disseminated disease evaluation and outcome in trilateral retinoblastoma

Br J Ophthalmol. 2018 Nov;102(11):1597-1601. doi: 10.1136/bjophthalmol-2018-312263. Epub 2018 Aug 27.

Abstract

Trilateral retinoblastoma (TRb) presents a management challenge, since intracranial tumours are seldom times resectable and quickly disseminate. However, there are no risk factors to predict the final outcome in each patient.

Objective: To evaluate minimal disseminated disease (MDD) in the bone marrow (BM) and the cerebrospinal fluid (CSF) at diagnosis and during follow-up and reviewing its potential impact in the outcome of patients with TRb.

Methods and analysis: We evaluated MDD in five patients with TRb, detecting the mRNA of CRX and/or GD2, in samples from BM and CSF, obtained at diagnosis, follow-up and relapse.

Results: Treatment involved intensive systemic chemotherapy in four patients, one did not receive this treatment and died of progression of the disease. Two patients underwent stem cell rescue. Three patients had leptomeningeal relapse and died. One patient remains disease-free for 84 months. RB1 mutations were identified in the five patients, all of them were null mutations. At diagnosis, one patient had tumour cells in the CSF, and none had the BM involved. Only one case of four presented MDD during follow-up in the CSF, without concomitant detection in the BM. On leptomeningeal relapse, no case had MDD in the BM. In all these cases, cells in the CSF were positive for GD2 and/or CRX.

Conclusion: CSF dissemination always concluded in the death of the patient, without concomitant systemic dissemination denoting the importance of increasing treatment directed to the CSF compartment. The MDD presence could indicate a forthcoming relapse.

Keywords: RB1 gene; bone marrow; intracranial tumor; leptomeningeal dissemination; neuroblastic tumor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Bone Marrow Cells / pathology
  • Brain Neoplasms / diagnosis*
  • Brain Neoplasms / drug therapy
  • Brain Neoplasms / genetics
  • Cerebrospinal Fluid Proteins / genetics
  • Child, Preschool
  • Female
  • Hematopoietic Stem Cell Transplantation
  • Homeodomain Proteins / genetics
  • Humans
  • Infant
  • Magnetic Resonance Imaging
  • Male
  • N-Acetylgalactosaminyltransferases / genetics
  • Neoplasm Recurrence, Local
  • Pineal Gland / drug effects
  • Pineal Gland / pathology*
  • Pinealoma / diagnosis*
  • Pinealoma / drug therapy
  • Pinealoma / genetics
  • RNA, Messenger / genetics
  • Retinal Neoplasms / diagnosis*
  • Retinal Neoplasms / drug therapy
  • Retinal Neoplasms / genetics
  • Retinoblastoma / diagnosis*
  • Retinoblastoma / drug therapy
  • Retinoblastoma / genetics
  • Retinoblastoma Binding Proteins / genetics
  • Retrospective Studies
  • Risk Factors
  • Trans-Activators / genetics
  • Transplantation, Autologous
  • Ubiquitin-Protein Ligases / genetics

Substances

  • Cerebrospinal Fluid Proteins
  • Homeodomain Proteins
  • RB1 protein, human
  • RNA, Messenger
  • Retinoblastoma Binding Proteins
  • Trans-Activators
  • cone rod homeobox protein
  • Ubiquitin-Protein Ligases
  • N-Acetylgalactosaminyltransferases
  • (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase