Pleural malignant mesothelioma versus pleuropulmonary synovial sarcoma: a clinicopathological study of 22 cases with molecular analysis and survival data

Pathology. 2018 Oct;50(6):629-634. doi: 10.1016/j.pathol.2018.06.001. Epub 2018 Aug 28.

Abstract

The aim of this study was to carry out a comparative analysis by transducin-like enhancer of split 1 (TLE1) immunohistochemistry and molecular analysis of SYT-SSX, for 16 pleural predominantly sarcomatoid mesotheliomas and six cases of pleuropulmonary synovial sarcoma (five pleural in distribution only, with one case of a predominantly subpleural upper lobe synovial sarcoma), all of which were solely or predominantly monophasic. Our comparison included survival and some clinical data. We consider that the following points emerged from this study.

Keywords: FISH; Pleura; RT-PCR; TLE1; age; biphasic; mesothelioma; monophasic; sarcoma; sarcomatoid; survival; synovial; t(X;18).

MeSH terms

  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor / analysis*
  • Co-Repressor Proteins
  • Diagnosis, Differential
  • Female
  • Humans
  • Lung Neoplasms / diagnosis*
  • Male
  • Mesothelioma / diagnosis*
  • Mesothelioma, Malignant
  • Middle Aged
  • Oncogene Proteins, Fusion / analysis
  • Oncogene Proteins, Fusion / biosynthesis
  • Pleural Neoplasms / diagnosis*
  • Repressor Proteins / analysis
  • Repressor Proteins / biosynthesis
  • Sarcoma, Synovial / diagnosis*

Substances

  • Biomarkers, Tumor
  • Co-Repressor Proteins
  • Oncogene Proteins, Fusion
  • Repressor Proteins
  • SYT-SSX fusion protein
  • TLE1 protein, human