Toxic Epidermal Necrolysis in a Patient with Autoimmune Limbic Encephalitis with Anti-Glutamate Receptor Antibodies

Keiko Hatano; Hideyuki Matsumoto; Akihiko Mitsutake; Junko Yoshimura; Aya Nomura; Sumihisa Imakado; Yukitoshi Takahashi; Hideji Hashida

doi:10.1159/000491690

Toxic Epidermal Necrolysis in a Patient with Autoimmune Limbic Encephalitis with Anti-Glutamate Receptor Antibodies

Case Rep Neurol. 2018 Aug 3;10(2):207-212. doi: 10.1159/000491690. eCollection 2018 May-Aug.

Authors

Keiko Hatano¹, Hideyuki Matsumoto¹, Akihiko Mitsutake¹, Junko Yoshimura², Aya Nomura², Sumihisa Imakado², Yukitoshi Takahashi³, Hideji Hashida¹

Affiliations

¹ Department of Neurology, Japanese Red Cross Medical Center, Tokyo, Japan.
² Department of Dermatology, Japanese Red Cross Medical Center, Tokyo, Japan.
³ Department of Pediatrics, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, Japan.

Abstract

We report on a 44-year-old woman who was diagnosed with toxic epidermal necrolysis (TEN) during the recovery phase from autoimmune limbic encephalitis with anti-glutamate receptor antibodies. Both, autoimmune limbic encephalitis and TEN are very rare diseases. The co-existence of the two diseases has not yet been reported. We speculate that the total of 18 drugs needed for the treatment of encephalitis might have increased the risk of TEN. Similar reports would be required to elucidate the pathophysiology of the co-existence.

Keywords: Anti-glutamate receptor antibodies; Autoimmune limbic encephalitis; Toxic epidermal necrolysis (TEN).

Publication types

Case Reports