Atypical Protein Kinase C: Breaking Down Barriers in Ocular Disease?

Elizabeth A Pearsall; Kip M Connor

doi:10.1016/j.ajpath.2018.07.006

Atypical Protein Kinase C: Breaking Down Barriers in Ocular Disease?

Am J Pathol. 2018 Oct;188(10):2142-2146. doi: 10.1016/j.ajpath.2018.07.006. Epub 2018 Sep 13.

Authors

Elizabeth A Pearsall¹, Kip M Connor²

Affiliations

¹ Angiogenesis Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts. Electronic address: elizabeth_moran@meei.harvard.edu.
² Angiogenesis Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts.

Abstract

This commentary highlights the article by Lin et al that demonstrates the therapeutic potential of small-molecule atypical protein kinase C inhibitors in inflammatory ocular disease.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Capillary Permeability*
Eye Diseases*
Humans
Inflammation
Protein Kinase C

Substances

PKC-3 protein
Protein Kinase C

Grants and funding

R01 EY027303/EY/NEI NIH HHS/United States