Dabrafenib plus trametinib in BRAF K601E-mutant melanoma

Br J Dermatol. 2019 Feb;180(2):421-422. doi: 10.1111/bjd.17250. Epub 2018 Nov 22.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Aged
  • Animals
  • Antineoplastic Combined Chemotherapy Protocols / pharmacology
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Humans
  • Imidazoles / pharmacology
  • Imidazoles / therapeutic use*
  • Male
  • Melanoma / drug therapy*
  • Melanoma / genetics
  • Melanoma / pathology
  • Mice
  • Mutation
  • Oximes / pharmacology
  • Oximes / therapeutic use*
  • Proto-Oncogene Proteins B-raf / antagonists & inhibitors
  • Proto-Oncogene Proteins B-raf / genetics
  • Pyridones / pharmacology
  • Pyridones / therapeutic use*
  • Pyrimidinones / pharmacology
  • Pyrimidinones / therapeutic use*
  • Skin / pathology
  • Skin Neoplasms / drug therapy*
  • Skin Neoplasms / genetics
  • Skin Neoplasms / pathology
  • Treatment Outcome
  • Xenograft Model Antitumor Assays

Substances

  • Imidazoles
  • Oximes
  • Pyridones
  • Pyrimidinones
  • trametinib
  • BRAF protein, human
  • Proto-Oncogene Proteins B-raf
  • dabrafenib