Ibuprofen Toxicity

Excerpt

Ibuprofen, 2-(4-isobutylphenyl) propionic acid, belongs to the class of nonsteroidal anti-inflammatory drugs (NSAIDs) and was discovered by Dr. Stewart Adams in 1961. The drug was first marketed in 1969 in the United Kingdom and in 1974 in the United States. Ibuprofen is commonly prescribed as an analgesic, antipyretic, and anti-inflammatory agent in conditions such as osteoarthritis, rheumatoid arthritis, juvenile idiopathic arthritis, and acute musculoskeletal pain. Off-label applications include its use in conditions such as cystic fibrosis to slow progression. Ibuprofen is also used to close patent ductus arteriosus in neonates. This resource serves to review ibuprofen's essential pharmacological characteristics, clinical presentations during an overdose, and management of ibuprofen toxicity.