Indirect activation of rhesus macaque (Macaca mulatta) NK cells in oral and mucosal draining lymph nodes

J Med Primatol. 2018 Oct;47(5):302-304. doi: 10.1111/jmp.12371. Epub 2018 Sep 6.

Abstract

The oral mucosae and draining lymph nodes are primary entry points for invading pathogens, particularly during immunosuppressive HIV/SIV infections. Innate immunity against oral stimuli, including natural killer (NK) cells, is understudied. Herein, we demonstrate functional NK cell responses to pathogen-associated molecular patterns (PAMPs) of potential oral pathogens in rhesus macaques.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Immunity, Innate*
  • Killer Cells, Natural / immunology*
  • Lymph Nodes / immunology*
  • Macaca mulatta*
  • Pathogen-Associated Molecular Pattern Molecules / pharmacology*
  • Simian Acquired Immunodeficiency Syndrome / immunology*

Substances

  • Pathogen-Associated Molecular Pattern Molecules