Predictive markers in lung cancer: a few hints for the practicing pathologist

M Barbareschi; M Barberis; F Buttitta; C Doglioni; M Fiorentino; G Fontanini; R Franco; A Marchetti; G Rossi; G Troncone

Predictive markers in lung cancer: a few hints for the practicing pathologist

Pathologica. 2018 Mar;110(1):29-38.

Authors

M Barbareschi¹, M Barberis², F Buttitta³, C Doglioni⁴, M Fiorentino⁵, G Fontanini⁶, R Franco⁷, A Marchetti³, G Rossi⁸, G Troncone⁹

Affiliations

¹ Pathology Unit, Hospital S. Chiara, Trento, Italy.
² Pathology Unit, European Institute of Oncology, Milan, Italy.
³ Center of Predictive Molecular Medicine, Center for Excellence on Aging and Translational Medicine, University of Chieti-Pescara, Italy.
⁴ Pathology Department, Vita Salute San Raffaele University, San Raffaele Scientific Institute, Milan, Italy.
⁵ Department of Pathology, Addarii Institute of Oncology, S. Orsola-Malpighi Teaching Hospital, University of Bologna, Italy.
⁶ Division of Pathological Anatomy, Department of Surgical, Medical, Molecular Pathology and Critical Care, University of Pisa, Italy.
⁷ Section of Anatomic Pathology Department of Public Health, University of Naples, Federico II, Italy.
⁸ Pathology Unit, Hospital S. Maria delle Croci, Azienda Romagna, Ravenna, Italy.
⁹ Pathology Unit, University of Campania "Luigi Vanvitelli", Naples, Italy.

PMID: 30259911

Abstract

This review article highlights some important points in the evolving area of predictive biomarkers determination in non-small-cell lung cancer toward standardization of testing practices, including EGFR mutations, ALK and ROS1 rearrangements and immunohistochemical expression of PD-L1. Considerations for selecting appropriate populations for molecular testing, and emergence of other targetable molecular alterations are also discussed.

Keywords: ALK; Carcinoma; EGFR; FISH; Immunoistochemistry; Lung; PCR; PDL1; ROS1.

Publication types

Review

MeSH terms

Anaplastic Lymphoma Kinase / genetics*
B7-H1 Antigen / metabolism
Biomarkers, Tumor / genetics*
Biomarkers, Tumor / metabolism
Biopsy
Carcinoma, Non-Small-Cell Lung / diagnosis
Carcinoma, Non-Small-Cell Lung / genetics*
Carcinoma, Non-Small-Cell Lung / metabolism
Carcinoma, Non-Small-Cell Lung / pathology
ErbB Receptors / genetics
Gene Rearrangement
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence
Lung Neoplasms / diagnosis
Lung Neoplasms / genetics*
Lung Neoplasms / metabolism
Lung Neoplasms / pathology
Mutation
Pathologists
Pathology, Molecular
Protein-Tyrosine Kinases / genetics*
Proto-Oncogene Proteins / genetics*

Substances

B7-H1 Antigen
Biomarkers, Tumor
CD274 protein, human
Proto-Oncogene Proteins
ALK protein, human
Anaplastic Lymphoma Kinase
EGFR protein, human
ErbB Receptors
Protein-Tyrosine Kinases
ROS1 protein, human