Spatial clonal evolution leading to ibrutinib resistance and disease progression in chronic lymphocytic leukemia

Haematologica. 2019 Jan;104(1):e38-e41. doi: 10.3324/haematol.2018.202085. Epub 2018 Sep 27.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenine / analogs & derivatives
  • Base Sequence*
  • Disease Progression
  • Drug Resistance, Neoplasm / genetics*
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell* / drug therapy
  • Leukemia, Lymphocytic, Chronic, B-Cell* / genetics
  • Leukemia, Lymphocytic, Chronic, B-Cell* / metabolism
  • Leukemia, Lymphocytic, Chronic, B-Cell* / pathology
  • Male
  • Middle Aged
  • Piperidines
  • Pyrazoles / administration & dosage*
  • Pyrimidines / administration & dosage*
  • Sequence Deletion*
  • Tumor Suppressor Protein p53* / genetics
  • Tumor Suppressor Protein p53* / metabolism

Substances

  • Piperidines
  • Pyrazoles
  • Pyrimidines
  • TP53 protein, human
  • Tumor Suppressor Protein p53
  • ibrutinib
  • Adenine